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    • Vabysmo
    • About
    • nAMD
    • DME
    • RVO
    • Real-World Data
    • Mechanism of Action
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      • nAMD
      • DME
      • RVO
      • Real-World Data
      • Mechanism of Action

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    1. Ophthalmology
    2. Vabysmo
    3. Mechanism of Action


    VEGF-A and Ang-2 drive retinal vascular disease together1-5

    ang2


    Start with the power of dual pathway inhibition1,6,7

    Fc region: Fragment crystallisable region is the tail region of the antibody

    References

    1. Regula JT, et al. EMBO Mol Med. 2016;8:1265–88.
    2. Augustin AJ, et al. Clin Ophthalmol. 2009;3:175–82.
    3. Heier JS, et al. Retina. 2021;41:1–19.
    4. Joussen AM, et al. Eye (Lond). 2021;35:1305–16.
    5. Larsen HO, et al. Ophth Ther. 2023;12:2253–64.
    6. Heier JS, et al. Lancet. 2022;399:729–40.
    7. Wykoff CC, et al. Lancet. 2022;399:741–55.
    8. VABYSMO®. SmPC https://go.roche.com/Vabysmo_SmPC Accessed May 2024
    9. VABYSMO®. Prescribing Information. https://www.gene.com/download/pdf/vabysmo_prescribing.pdf Accessed May 2024

    M-PK-00002048

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